PLATINUM – RED LABEL COMPLETE SUPPLEMENT PACKS
Platinum – Red Label Complete Supplement Packs may be helpful for supporting those in recovery from heroine and opiates.
Pro Recovery Rx Platinum- Red Label is a revolutionary approach to nutritional supplementation for those experiencing the negative impacts most commonly associated with the use of opiates.
A unique feature of Platinum Red Label is the focus on the dopamine reward pathway. Often those that have abused opiates, heroin, methadone and suboxone have depleted dopamine. Red label is formulated to support the rejuvenation of the dopamine pathway, which is imperative to recovery. Most people who abuse opioids have feelings of discontentment, irritability and restlessness and our Platinum-Red Label will support a smoother mood, improve energy and focus.
Platnium- Red Label is not only based on science but it is also a comprehensive, easy to use and easy to follow nutritional supplementation system. Using Platnium- Red Label ensures that you don’t miss taking any necessary nutritional supplements thereby improving potential outcomes.
PLATINUM – RED LABEL
Complete Supplement Packs
(90 Capsule Packets)
Order your supply of Platinum – RED Label $299.00.
Subscribe Today and Save 10%
SUBSCRIBE & SAVE ON FUTURE ORDERS
- Set up recurring shipment & save 10%.
- Be sure you never run out.
- Lock in your price.
- Get VIP access to exclusive sales and offers
- Change your shipping schedule anytime.
Platinum Red Label Complete Supplement Packs
Order your supply of Platinum Red Label
Pro Recovery Rx ‘Platinum Red Label’ is a revolutionary approach to nutritional supplementation for those experiencing the negative impacts most commonly associated with the use of opiates.
Platinum Red Label is not only based on science but it is also a comprehensive, easy to use and easy to follow nutritional supplementation system. Using Red Label ensures that you don’t miss taking any necessary nutritional supplements thereby improving potential outcomes.
Platinum Red Label Complete Supplement Packs may be helpful for:
- Providing the building blocks for neurotransmitters, particularly the catecholamines (dopamine/norepinephrine/epinephrine)
- Brain Health
- Supports Steady Energy levels
- Positive mental outlook
- Healthy Response to Stress
- GI Health
- Liver Health
- Lung Health
- Maintaining a healthy immune system
- Supporting healthy circulation
- Protect the body from oxidative damage
- A healthy inflammatory response
- Antioxidant response
- Optimal detoxification
When to Take Each Packet: Other amino acids compete with some Red Label Ingredients for absorption, so in order to effectively optimize its use, some individuals may benefit from taking each supplement pack separately from other protein-rich foods. Because of the stimulating effect of Red Label, it may impact sleep if taken too late in the day. If this is the case, adjust the timing to meet your needs.
Interactions with Drugs: Due to competition for absorption in the small intestine, the supplement MaxElevate in Red Label may decrease the effectiveness of L-dopa (Levodopa). If you take L-dopa, wait at least 2 hours before taking MaxElevate. MaxElevate supplementation may also increase the effect of drugs that affect dopamine metabolism (consult with your health care practitioner). For safety sake, take each packet 1-2 hours from any prescription medication.
Who Should Not Take Platinum Label? Platinum Label should not be taken by those with diagnosed with heart conditions including high blood pressure, schizophrenia, manic conditions, anxiety, insomnia, or cancer (including skin cancer), without consulting their health care practitioner. Red Label may interfere with the effectiveness of antipsychotic drugs.
*If any unwanted side effects occur, discontinue use and seek medical attention.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult with your healthcare practitioner about your specific circumstances and any questions you may have.
Why do I need Red Label as a part of my addiction recovery?
There are many schools of thought when it comes to addiction recovery. What we are learning is that without good brain health your chances of relapse are greater. Many people have subscribed to the ‘white knuckle’ approach to recovery which is outdated. Thankfully science is beginning to catch up to the addiction recovery process. What we know is that through addiction your brain and body has been deprived of essential nutrients. This has impaired the neurotransmission process which is vital to recovery, mood, sleep, etc. You no longer need to ride out time in your recovery process. You can be an active participant fueling your brain and body with rich nutrition and amino acids so your recovery is balanced.
Pro Recovery Rx Red Label helps you fill in the nutritional and amino acids gaps so the brain recovery process after addiction is faster and more productive. This allows you to feel better in your recovery and focus on the things that matter most in your life.
What is a neurotransmitter?
Neurotransmitters are chemical messengers that regulate physical and emotional processes including movement, stress response, cognition, emotions, energy, cravings, pain and more. Imbalanced neurotransmitter function disrupts the signal and has a profound impact on your health, mental health, addiction process, and general well-being.
When neurotransmitters are imbalanced you might be reaching for other substances including sugar, caffeine, alcohol, nicotine and prescription medications and drugs. This further contributes to neurotransmitter imbalance and worsens symptoms.
When functioning properly, the neurotransmission system has natural checks and balances in the form of excitatory and inhibitory neurotransmitters. When balanced you will feel more emotional stability, less cravings and have more energy and drive.
What are amino acids?
Amino acids, often referred to as the building blocks of proteins, are compounds that play many critical roles in your body. They’re needed for vital processes like the building of proteins and synthesis of hormones and neurotransmitters.
While essential amino acids can be found in a wide variety of foods (particularly animal proteins), taking concentrated doses of amino acids as supplements has been linked to many health and mental health related benefits.
What we know is that many people in the throws of addiction and early recovery are not fueling their bodies with nutritious food. This has starved the brain for a long period of time.
Pro Recovery Rx has taken the information about brain health and addiction and has combined it with the knowledge of amino acids and nutrient co-factors to bring you Red Label. With proper amino acid and nutrient co-factor supplementation we take the guesswork out of brain health recovery freeing you up to worry about the things in your recovery process that are the most important to you.
Who is Red Label for?
Red label was specially formulated for individuals who have been addicted to opioids and stimulants. This includes pain killers, heroin and even stimulants such as aderall. Red label was formulated to balance neurotransmitters that have been negatively influenced by the use, abuse and dependence of opioids and stimulants.
What should I expect from Red Label?
Red label is rich in the amino acids that influence the Dopamine pathway. The dopamine pathway is basically in charge of your motivation, drive and reward system. When your reward system is hijacked from drugs such as painkillers and heroin you will crash and feel fatigued, sluggish and unmotivated. Red label formulation will begin to rebuild the pathway and over time you will get your drive back.
What shouldn’t I expect from Red Label?
Red Label is not a quick fix, nothing is. Red label will not fix your relationships, your money problems or be a replacement for the things in your life that have been destroyed due to addiction. Red label is a catalyst for a healthy life.
How will I know if it’s working?
Many people who struggle with addiction are looking for a quick fix or a short term solution to addiction. Red Label will take some consistency on your part. Daily use of Red Label will begin to rebuild your dopamine pathway and within a few weeks of consistent use you will feel more alert, bright and have some internal drive again. The changes are subtle. They are not a ‘high’ that you may be accustomed to. For instance, if you feel fatigued you might notice that your eyes and forehead are heavy but after taking Red Label your eyes will feel open and you will yawn less. Instead of turning to caffeine or energy drinks to get your motor running, Red Label will actually give your body and brain what it is needing, not another cover up or reliance on caffeine or stimulants.
Will this give me a buzz?
No, Red Label is not designed to give you a buzz. Many people will take products that use high doses of caffeine or other super stimulating ingredients (think working out products) that will give you a quick buzz and then a debilitating crash. Red label rebuilds your reward pathway but will not give you a buzz or a crash. It will even out mood and energy which is what your brain is really searching for.
How long should I take it?
How the brain recovers from addiction is an exciting and emerging area of research. There is evidence that the brain does recover. Some research suggests that after 14 months of abstinence, the dopamine transporter levels (DAT) in the reward region of the brain (an indicator of dopamine system function) return to nearly normal function. However, many people relapse far before 14 months of brain recovery has happened. That is why ProRecovery Rx is a necessary part of addiction recovery. With proper brain health and neurotransmitter balance you could shorten the amount of time it takes for your brain to return to normal function. How long you take the product is dependent upon you. Most people can feel a benefit within a few weeks. However, a consistent balanced benefit typically will occur around 6 months. We recommend that you continue to take the product until you feel you no longer need it. After that, you can switch over to the Gold product to keep things in check. Red Label is not designed to be taken for a lifetime.
Will I have to keep track of a bunch of supplements/pills every day?
No, we have taken all of the guess work out of using supplements. Each day you will have 3 doses of prepacked supplements. All you need to do is fit the packs into your daily life. You won’t have a bunch of supplement bottles to keep track of. You won’t have to pack your own supplements. We have taken all of the guesswork out of the process for you so you can focus on things in your recovery process that are the most meaningful to you.
Is this medication?
No, Pro Recovery Rx is not prescription medication. It is comprised of vitamins, minerals, and amino acids.
Can I take this with my medication?
For anyone on any kind of prescription medication, you should always check with your prescribing doctor or pharmacist for drug interactions. Typically you should not take Pro Recovery Rx at the same time as a prescription medication. It is advisable to take at least 1-2 hours away from prescription medication as long as a medication interaction is not present.
Who should not take Red Label?
Though amino acids are typically safe, there are some instances that you should not take them and consult with your medical professional.
- High Blood Pressure
- Heart Conditions
- Migraine Headaches
- Bipolar tendancies
- Overactive thyroid
Consult with your physician before using any amino acids if you have any of the following:
- If you tend to react negatively to supplements
- You have a serious physical illness, particularly cancer
- You have severe liver or kidney problems
- You have an ulcer
- You are pregnant or nursing
- have schizophrenia or other serious mental illness
- You have phenylkentonuria
- You are taking any medications for mood problems, particularly MAO inhibitors or more than one SSRI/SNRI
Are there any negative side effects of Red Label?
Typically there is not. However, if you feel overly anxious, jittery or just plain unusual, discontinue using immediately and seek medical attention.
Multi Without Iron
Balanced Profile Vitamins and minerals work synergistically and cooperatively when present in proper amounts. However, imbalances between micronutrients can disrupt this synergistic relationship, possibly leading to instances of competitive intestinal absorption or displacement at the metabolic/cellular level, which can produce relative excesses and insufficiencies. For this reason, Multi Without Iron formulas feature a balanced nutrient profile that includes calcium and magnesium, zinc and copper, vitamins C and E, bioactive folate, vitamin B12, B vitamin complex, beta-carotene, and trace elements.*
Bioavailability- The micronutrients are provided in bioavailable forms so that they can be better absorbed and utilized. Multi Without Iron formulas contain a full complement of Albion® patented mineral chelates and complexes. Albion is a recognized world leader in mineral amino acid chelate nutrition and manufactures highly bioavailable nutritional mineral forms that are validated by third party research and clinical studies. Not only do these formulas contain natural vitamin E, which has been proven to be up to 100% more bioavailable than synthetic dl-alpha-tocopherol, but it is also provides mixed tocopherols to more closely approximate how one might consume vitamin E in healthful foods.[9,10] Folate is provided as 5-methyltetrahydrofolate (5-MTHF)—the most bioactive form of folate. Multi Without Iron formulas feature 5-MTHF as Quatrefolic®, which is proven to have greater stability, solubility, and bioavailability over calcium salt forms of 5-MTHF. Vitamin B12 is provided as MecobalActive™. This patented form of methylcobalamin has very high purity; no harmful solvents are used in its production. Vitamins B2 and B6 are also provided in activated forms.*
Energy Production Multi Without Iron formulas provide generous levels of B vitamins, which serve as prime coenzymes in glycolysis and oxidative phosphorylation and as cofactors in amino acid and lipid metabolism. The balanced presence of B vitamins is essential to their cooperative functioning and excellent for those with stressful lifestyles.* Antioxidant Protection Vitamins E and C, selenium, zinc, beta carotene, and trace elements provide broad-spectrum antioxidant activity. Their combined presence supports their ability to regenerate each other and maintain consistent levels of antioxidant activity both intra- and extracellularly.* Detoxification Support Xenobiotics, including environmental pollutants and medications, must undergo biotransformation into molecules that can be easily excreted from the body. There are significant levels of bioavailable riboflavin, niacin, folate, and B12 present in these formulas to support phase I detoxification. Beta carotene, vitamin C, tocopherols, selenium, copper, zinc, and manganese are present to protect tissues from reactive intermediates formed between phase I and phase II detoxification.*
This high-quality, hypoallergenic, multivitamin/mineral blend includes activated vitamins; folate as Quatrefolic® (5-MTHF) for optimal utilization; and patented Albion® TRAACS® chelated mineral complexes in vegetarian capsules. The comprehensive nutrient profile in Multi Without Iron® supports foundational wellness; antioxidant activity with vitamins C and E, selenium, and beta-carotene; and phase I detoxification.*
MCHC plus Mag
Numerous published studies support the safety, tolerability, and bone health-related effectiveness of MCHC supplementation.[1,2] Studies suggest that the bioavailability of calcium from MCHC supplements may be as good as or better than the bioavailability of calcium from calcium gluconate supplements.[3,4]
PRx Products utilize standardized, safe, bovine-sourced MCHC from New Zealand, a country with stringent standards. Its production features a proprietary technique that preserves the bioactive contents of bone. This process creates a naturally balanced formula because whole bone extract provides all of the nutrients found in healthy bone.* Unlike other calcium supplements on the market, MCHC plus Mag consists of collagenous and non-collagenous proteins and peptides. These compounds include insulin-like growth factors I and II (IGF-I, IGF-II), transforming growth factor beta (TGF-beta), and osteocalcin, factors that stimulate alkaline phosphatase activity and support metabolism in human bone cells. Removal of the protein fraction appears to reduce the positive effects of the formula, highlighting the importance of its presence.* A study suggested that the occurrence of positive and statistically significant changes in forearm bone integrity were the result of daily supplementation with 3000 mg of microcrystalline hydroxyapatite.
Earlier studies compared MCHC plus Mag to other forms of calcium with regard to the support of normal bone turnover and bone mineral integrity. In one 20-month, double-blind study, women were given 1400 mg of elemental calcium (equivalent to approximately 5000 mg MCHC) as either calcium carbonate or MCHC plus Mag. At the end of the study, the presence of bone integrity was statistically significant in the MCHC plus Mag group.* Clinical trials suggested that MCHC plus Mag supplementation was well tolerated and yielded a positive outcome for dental status, bone integrity, and healthy bone metabolism.[9,10] A randomized, controlled study indicated that the addition of MCHC plus Mag to exogenously administered hormones provided statistically significant support (4.7%, P<0.1) to vertebral bone mass. Another study of 60 subjects suggested that bone mass was maintained while on MCHC plus Mag.* MCHC plus Mag is high-quality MCHC from New Zealand.
The World Organization for Animal Health (the OIE) has classified New Zealand as a “negligible BSE risk country,” the most favorable official classification a country can be given. MCHC plus Mag is manufactured under proprietary processes that meet FDA, USDA, and EU regulatory requirements. Gentle processing is used to retain the delicate protein matrix and organic factors. X-ray-diffraction analysis confirms the microcrystalline structure. The MCHC is assayed for hydroxyproline content. The collagen content is greater than 22% with the majority being type l, the predominant collagen occurring in bone. Frequent heavy metal assays assure purity. MCHC plus Mag 1100™ delivers 1100 mg of MCHC plus Mag per capsule. MCHC plus Mag MD™ delivers 500 mg of MCHC plus Mag per capsule along with vitamin D, magnesium, and additional calcium. Vitamin D is provided as cholecalciferol, which stimulates intestinal calcium absorption and helps support calcium and phosphorus homeostasis in the body. Calcium is provided as MCHC and DimaCal® dicalcium malate, and magnesium is provided as Albion dimagnesium malate and TRAACS® magnesium bisglycinate chelate. The buffering malate forms of calcium and magnesium do not react with stomach acid and are less likely than carbonates to cause discomfort and acid rebound.*[13
N-Acetyl-L-Cysteine (NAC) is a source of the conditionally essential amino acid L-cysteine and a precursor to the tripeptide glutathione. NAC and glutathione support antioxidant and detoxification activity in the body.*
NAC (N-acetyl-cysteine) NAC, a sulfur-containing derivative of the amino acid L-cysteine, supports antioxidant and detoxification mechanisms in the body. NAC supports antioxidant activity by neutralizing hydrogen peroxide, hypochlorous acid, and the highly reactive hydroxyl radical and also serves as a source of sulfhydryl groups. In addition, NAC enhances production of the tripeptide glutathione—a key component of both antioxidant and detoxification enzymes.* NAC is recognized for its support of normal mucous production and may positively support respiratory function and eye health, especially when consumed over a prolonged period.[1-3] Research suggests that NAC may protect cell and tissue health by supporting normal metal status in the body.*[1,4,5]
Glutathione – While the absorption of oral glutathione may be limited, supplementation with NAC may significantly increase circulating levels of glutathione in the body.[7,8] Once NAC promotes production of glutathione, glutathione is incorporated into crucial antioxidant enzymes (e.g., glutathione peroxidase and glutathione reductase) and detoxification enzymes (glutathione S-transferases). Through the activity of these enzymes, glutathione directly supports antioxidant activity, phase II detoxification, and the normal breakdown of metabolites, toxins, and other compounds in the body. Glutathione also participates in fatty acid synthesis and amino acid transport across the cell membrane.* A variety of factors may determine glutathione requirements, including level of exposure to toxins, increased phase I detoxification activity, and overall need for antioxidant support. Maintaining glutathione levels may be important to maintaining the health of the respiratory, hepatic, and immune systems, as well as supporting antioxidant protection of lipids and proteins and supporting the normal response to inflammation.[7-13] Levels of endogenous antioxidants, including glutathione, may decrease with age. It is important to maintain adequate levels of glutathione in the body to support overall health and well-being throughout the lifespan.*
Vitamin D3 5000
While vitamin D3 (cholecalciferol) is made in the skin when 7-dehydrocholesterol reacts with sunlight, many things affect the degree to which this biosynthesis occurs, including time of day, seasons, location, smog/pollution, clothing, shade of skin (darker skin requires more sun), and sunscreen use. Low-cholesterol diets and certain cholesterol therapies can also affect vitamin D formation. By some estimates, one billion people worldwide have vitamin D deficiency or insufficiency.
Reversing deficiency and maintaining optimal serum vitamin D levels beneficially impacts biochemistry and numerous body systems; this is largely because calcitriol—the metabolic product of vitamin D—is a secosteroid hormone that targets over 200 genes in a wide variety of tissues.[2,3] As the research demonstrates, vitamin D is clearly imperative for the development, growth, and maintenance of a healthy body from gestation to senescence.* Bone Health The body needs vitamin D to absorb calcium, and the importance of vitamin D in skeletal health and bone density is well established. Although bone density is most often associated with calcium intakes, insufficient vitamin D negatively affects calcium absorption. Without adequate absorption, the body must take calcium from its stores in the skeleton, which weakens existing bone and prevents the formation of strong, new bone.
Clinical research shows that taking vitamin D orally with calcium supplements can support healthy bone turnover[4-6], and adequate calcium and vitamin D throughout life—as part of a well-balanced diet—may reduce the risk of osteoporosis.* The Expanding Roles of Vitamin D The role of vitamin D in good health continues to expand as the knowledge of this vitamin’s effects on different body systems grows. Research now suggests that optimal serum levels of vitamin D support normal cell differentiation,[3,7] cardiovascular health,[2,3] normal immune function, good balance, healthy mood, normal fetal development, neuronal growth and neurodevelopment,[2,3,10,11] healthy glucose metabolism,[2,3] musculoskeletal comfort,[2,3] periodontal health, and normal intestinal immune responses.
Areas of research that have gained momentum over the past several years concern the relationship of vitamin D deficiency or insufficiency to changes in cellular proliferation, changes in fetal brain development, and mental health. [7,10,13-15] Evidence is also mounting that vitamin D supplementation may provide key immune support.*[16-19] D2, D3, and Metabolites As previously stated, D3 is the form of vitamin D produced in the skin. D2 (ergocalciferol) is derived from fungal sources by activating ergosterol with ultraviolet light. It is not naturally present in the human body. After vitamin D is formed in the skin or taken orally, it is metabolized into two different substances within the body: calcidiol (25-hydroxyvitamin D) and calcitriol (1,25-dihydroxyvitamin D). Calcidiol is the body’s main storage form of vitamin D, while calcitriol (made from calcidoil) is “activated” vitamin D. Although D2 and D3 are similar biochemically, a recent study reported D3 to be approximately 87% more potent in raising and maintaining serum calcidiol concentrations and in producing two- to threefold greater storage of vitamin D than did equimolar D2.*[20
Each Tyrosine NAC capsule contains 400 mg of L-tyrosine, a conditionally essential amino acid the body can convert to the neurotransmitters dopamine, epinephrine, and norepinephrine. These neurotransmitters are found to increase mental alertness and focus and also preserve normal memory under stressful conditions. N-acetyl-Lcysteine is present to support glutathione production, antioxidant activity, and neuronal protection.*
Tyrosine, or 4-hydroxyphenylalanine, a proteogenic, non-essential amino acid that can be synthesized in the body from phenylalanine, is converted into dopamine, epinephrine, and norepinephrine. Although present in foods such as dairy, eggs, soy, peanuts, sesame, seaweed, avocados, bananas, poultry, lima beans, and others, tyrosine, when consumed in food, must compete for absorption with the other amino acids present. Taken as a supplement, tyrosine does not have to compete with other amino acids and, therefore, its full benefits can be realized.*
Stress conditions, such as a cold environment, psychological stress, sleep deprivation, and strenuous, prolonged athletic activity, appear to reduce the body’s ability to convert phenylalanine to tyrosine. This underproduction may manifest itself as poor memory and performance. Tyrosine, as a precursor for catecholamine synthesis, presumably augments brain catecholamine levels and improves working memory under stress. Tyrosine also supports adrenal and pituitary function, and may increase thyroid hormone. Additionally, it is necessary for production of the skin pigment, melanin. Oral contraceptives may cause a decline in tyrosine plasma levels, possibly because estrogen can increase glucocorticoid levels. This, in turn, elevates levels of tyrosine aminotransferase, which degrades tyrosine in the liver.*
Although increased dopamine may be beneficial in some circumstances, excessive synthesis of this neurotransmitter generates hydoxy radicals that stress glutathione levels. N-acetyl cysteine (NAC), a derivative of the amino acid, L-cysteine, is the precursor to glutathione and helps augment the body’s reserve of this important antioxidant. It has been included in this formula primarily to protect the neurons against dopamine toxicity. However, NAC also lessens the load on the methylation cycle, thereby decreasing the load on the THB cycle and promoting the conversion of tyrosine to dopamine.* Only a percentage of the tyrosine consumed will make it into the brain for conversion to catecholamines. The rest will be picked up for structural protein usage, etc. The only component that needs to be balanced with a glutathione precursor is the portion of tyrosine that is converted into catecholamines. For this reason, less NAC than tyrosine is present.*
Adrenal Booster™ pairs glandulars with targeted nutrients to support the body’s response to everyday stressors. Among the comprehensive blend of nutrients are high-potency pantothenic acid and vitamin C, activated B vitamins, and mineral amino acid chelates. Gland and organ tissues are derived from an Argentinian bovine source that ensures safety and purity.*
Stress is caused by physiological, psychological, or emotional triggers (stressors) that cause a disturbance in the homeostasis of an organism. How we respond to those stressors (physiologically and psychologically) influences how well we cope with change and with ongoing stress. Structural or physical trauma, distress, poor diet, infection, toxic exposure, leaky gut, births, deaths, lack of sleep, temperature changes, electromagnetic radiation, and allergies or food sensitivities are all potential stressors. Combined, they amount to a total stress level and can ultimately disrupt homeostasis with direct effects on the autonomic nervous system, the hypothalamic-pituitaryadrenal (HPA) axis, and the cardiovascular, metabolic, and immune systems.
Specifically, research reveals that prolonged stress has a profound effect on the adrenal glands, lymph nodes, thymus gland, and gastrointestinal system. Endocrinologist Hans Selye identified the various stages of the stress response (alarm, resistance, and exhaustion) and described the entire phenomenon as the general adaptation syndrome (GAS). Micronutrients, such as vitamins, minerals, and antioxidants, are involved in the majority of metabolic functions in the body. B vitamins are especially important to energy generation within the cellular mitochondria, and a deficiency of any B vitamin can compromise mitochondrial function.[3,4] Riboflavin supports the respiratory chain, niacin supplies protons for oxidative phosphorylation, and pantothenic acid is required for coenzyme A production, metabolic enzyme complex formation, and fatty acid oxidation. Stressors can increase metabolic demand, energy expenditure, and micronutrient needs.
Micronutrient sufficiency and balance have been established as crucial to helping maintain a healthy psychological and physiological response to stress. Unfortunately, experts estimate that a significant proportion of the general population does not consume adequate dietary levels of several micronutrients. Experts suggest that exogenous supplementation can improve micronutrient status and sufficiency and help support a healthy response to stress.* Clinical research supports the premise that micronutrient supplementation can favorably support the stress response in a variety of circumstances.
In a randomized, double-blind, placebo-controlled (RDBPC) trial, high-potency doses of B vitamins and vitamin C along with an array of minerals were studied for their effects on perceived stress scores (measuring one’s self perception of stress) in 215 males aged 30 to 55 years. Results revealed significant improvements on the perceived stress scale (PSS), the profile of mood states (POMS), and the general health questionnaire (GHQ-12) for those taking the multivitamin/mineral supplement. Another RDBPC study of 80 males revealed consistent and statistically significant modulation in anxiety and perceived stress in the men who took a high-potency multivitamin/mineral supplement compared to those who took the placebo. Participants taking the supplement also reported feeling less tired and better able to concentrate compared to their placebotaking counterparts. Similar results were achieved in a double-blind, placebo-controlled, double-center study of 300 subjects taking a multivitamin/mineral supplement, with significant improvement in baseline stress scores. The levels of vitamin C, riboflavin, B6, pantothenic acid, and zinc provided in the recommended dose of two Adrenal Booster capsules twice daily meets or exceeds the levels used in these clinical studies. The recommended daily dose of four capsules also provides 30 mg of niacin (compared to 50 mg used in studies) and 90 mg of magnesium (compared to 100 mg used in studies).*
Adrenal Booster also contains a blend of complementary nutrients and purified glandulars. Rhodiola rosea, chlorella, grape seed extract, magnesium, zinc, chromium, bioflavonoids, and L-tyrosine are present at levels that allow for additional supplementation to round out their profile. Activated B vitamins and Albion® TRAACS® (the real amino acid chelate system) mineral amino acid chelates, along with other chelated minerals, are key features of the formula. Adrenal, parotid, thymus, and spleen glandulars are extracted from an Argentinian bovine source that ensures safety and purity.*
Niacin 750 is one of the most studied and documented nutrients for support of lipid levels already within the normal range, especially high-density lipoprotein cholesterol (HDL-C) levels. Sustained release niacin, as found in Niacin 750, has a lesser flushing effect compared with instant-release niacin. Use of a proprietary, wax-coated technology permits release that is complete in seven to eight hours, the time that is considered ideal for a time release form of niacin.*
The cardiovascular benefits of niacin (vitamin B3) were introduced in the June 1956 issue of Mayo Clinic Proceedings.  More than 20 years later, the Framingham Heart Study touted the benefits of niacin on lipid metabolism. A decade later, as the study continued, researchers labeled niacin “front-line” cardiovascular support. This status was further reinforced in 1988 when the National Cholesterol Education Program (NCEP) panel designated niacin a “first-line therapy” for support of specific parameters related to cardiovascular health.* Mechanisms of Action Several mechanisms of action have been proposed for niacin. Various experimental models suggest niacin can modulate lipoprotein biosynthesis in the liver, inhibit the release of free fatty acids from adipocytes, inhibit synthesis of apo B, induce lipoprotein lipase, and help maintain the structure and function of HDL (high-density lipoprotein) by reducing the amount of apo A-1 broken down from HDL during hepatic processing.[4,5]
In addition, when niacin is used with resins, it can stimulate bile flow and may therefore affect lipid biosynthesis.* Human Trials Since the late 1970s, studies and clinical trials, lasting from four weeks to five years with daily doses of extended-release (also known as sustained/prolonged/slow-release) niacin up to 3000 mg/day, have consistently demonstrated niacin’s efficacy and safety.  In 2004, the ARBITER 6-HALTS trial clearly demonstrated that niacin offers targeted support of cardiovascular health. Final results of this trial, published in 2010, further demonstrated that niacin supports healthy carotid intima-media thickness (CIMT). While the supportive effect niacin has on blood lipids is well documented, there has been a recent focus by NCEP and other researchers on how niacin’s effect on HDL may influence cardiovascular events. More well-designed studies that address innate limitations and are carried to completion are needed.*
Why Isn’t Niacin More Widely Used? The two common concerns are cutaneous flushing and increased liver enzymes. Cutaneous flushing is harmless, although it can be a nuisance. Flushing is most often seen with the use of immediate/instant-release forms of niacin and can occur with doses as low as 30 mg/day, but it is more likely to occur with the much higher doses used to support healthy blood lipids. Flushing may last 10 to 15 minutes and rarely, but possibly, up to two hours. The proprietary wax-coated technology used in Niacin 750 tablets allows a gradual, sustained release of niacin over a seven-to-eight hour period. This delivery dramatically reduces the flushing associated with immediate-release forms. Adherence to a regimen with the special wax-coated form of niacin, as found in Niacin 750, ranged from 88-97% in four human clinical trials.[10,11] Flushing, itching, tingling, and upper gastrointestinal side effects were minimal, but did increase when dosing was increased to 2000 mg/day.
It is important to note that Niacin 750 should not be confused with “no-flush” niacin, which is inositol hexanicotinate (IHN), a supplement that does not contain any free niacin and may not be as supportive of cardiovascular health as those providing nicotinic acid.*[12,13] The second concern with regard to liver enzyme elevation was first elucidated by the results of McKenney’s study, published in 1994 in the Journal of the American Medical Association (JAMA), wherein subjects received 3000 mg/day of niacin over an extended period of time. In April 2004, McKenney retracted his earlier warnings about the harmful effects of niacin and publicly supported its unique benefits. Although they generally do not enter an unhealthy range, liver enzymes may increase when initiating niacin therapy, especially in amounts greater than 1000 mg/day. Enzyme levels return to normal promptly after cessation of niacin.*
Multi w/o iron
Ames BN. A role for supplements in optimizing health: the metabolic tune-up. Arch Biochem Biophys. 2004 Mar 1;423(1):227-34. [PMID: 14989256]
Toffanello ED, Inelmen EM, Minicuci N, et al. Ten-year trends in vitamin intake in free-living healthy elderly people: the risk of subclinical malnutrition. J Nutr Health Aging. 2011 Feb;15(2):99-103. [PMID: 21365161]
Block G, Jensen CD, Norkus EP, et al. Usage patterns, health, and nutritional status of long-term multiple dietary supplement users: a cross-sectional study. Nutr J. 2007 Oct 24;6:30. [PMID: 17958896]
Fletcher RH, Fairfield KM. Vitamins for chronic disease prevention in adults: clinical applications. JAMA. 2002 Jun 19;287(23):3127-29. [PMID: 12069676]
Moshfegh AJ, Goldman JD, Ahuja JK, et al. U.S. Department of Agriculture, Agricultural Research Service. What we eat in America, Nhanes 2005-2006. Usual nutrient intakes from food and water compared to 1997 dietary reference intakes for vitamin D, calcium, phosphorus, and magnesium. http://www.ars. usda.gov/SP2UserFiles/Place/12355000/pdf/0506/usual_nutrient_intake_vitD_ ca_phos_mg_2005-06.pdf Published July 2009. Accessed February 22, 2011.
What we eat in America. WIN Notes. Weight Control Information Network. http://win.niddk.nih.gov/notes/winter99/artcl6.htm. Accessed July 22, 2011.
Alexy U, Libuda L, Mersmann S, Kersting M. Convenience foods in children’s diet and association with dietary quality and body weight status. Eur J Clin Nutr. 2011 Feb;65(2):160-66. [PMID: 21139631]
Kiyose C, Muramatsu R, Kameyama Y, et al. Biodiscrimination of alphatocopherol stereoisomers in humans after oral administration. Am J Clin Nutr. 1997 Mar;65(3):785-89. [PMID: 9062530]
Burton GW, Traber MG, Acuff RV, et al. Human plasma and tissue alphatocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E. Am J Clin Nutr. 1998 Apr;67(4):669-84. [PMID: 9537614]
Venn BJ, Green TJ, Moser R, et al. Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study. Am J Clin Nutr. 2003 Mar;77(3):658-62. [PMID: 12600857]
Sallares J, Petschen I, Camps X, inventors; Ferrar Internacional, S.A., applicant. Process for the production of methylcobalamin. International publication number [English] WO 2006100059 A1. September 28, 2006
Brame AL, Singer M. Stressing the obvious? An allostatic look at critical illness. Crit Care Med. 2010 Oct;38(10 Suppl):S600-7. [PMID: 21164403]
Szabo S, Tache Y, Somogyi A. The legacy of Hans Selye and the origins of stress research: a retrospective 75 years after his landmark brief “letter” to the editor of Nature. Stress. 2012 Sep;15(5):472-8. [PMID: 22845714]
Depeint F, Bruce WR, Shangari N, et al. Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism. Chem Biol Interact. 2006 Oct 27;163(1-2):94-112. [PMID: 16765926]
Angelo G. What is metabolism? Linus Pauling Institute. http://lpi.oregonstate. edu/ss13/metabolism.html. Accessed October 19, 2013.
Askew EW. Environmental and physical stress and nutrient requirements. Am J Clin Nutr. 1995 Mar;61(3 Suppl):631S-637S. Review. [PMID: 7879730]
Schlebusch L, Bosch BA, Polglase G, et al. A double-blind, placebo-controlled, double-centre study of the effects of an oral multivitamin-mineral combination on stress. S Afr Med J. 2000 Dec;90(12):1216-23. [PMID: 11234653]
Drake V. Micronutrients and Cognitive Function. Linus Pauling Institute. http:// lpi.oregonstate.edu/infocenter/cognition.html. Accessed October 12, 2013
Kennedy DO, Veasey R, Watson A, et al. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology (Berl). 2010 Jul;211(1):55-68. [PMID: 20454891]
Carroll D, Ring C, Suter M, et al. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial. Psychopharmacology (Berl). 2000 Jun;150(2):220-5. [PMID: 10907676]
Growdon JH. Effects of oral L-tyrosine administration on CSF tyrosine and homovanillic acid levels in patients with Parkinson’s disease. Life Sci. 1982 Mar 8;30(10):827-32. [PMID: 6175872]
O’Brien C, et al. Dietary tyrosine benefits cognitive and psychomotor performance during body cooling. Physiol Behav. 2007 Feb 28;90(2-3):301-7. Epub 2006 Oct 31. [PMID: 17078981]
Palinkas LA. Mental and cognitive performance in the cold. Int J Circumpolar Health. 2001 Aug;60(3):430-9. [PMID: 11590885]
Deijen JB, Orlebeke JF. Effect of tyrosine on cognitive function and blood pressure under stress. Brain Res Bull. 1994;33(3):319-23. [PMID: 8293316]
Magill RA, et al. Effects of tyrosine, phentermine, caffeine D-amphetamine, and placebo on cognitive and motor performance deficits during sleep deprivation. Nutr Neurosci. 2003 Aug;6(4):237-46. [PMID: 12887140]
Rose DP, Cramp DG. Reduction of Plasma Tyrosine by Oral Contraceptives and Oestrogens: A Possible Consequence of Tyrosine Aminotransferase Induction, Clin Chim Acta, 1970;29:49-53. [PMID: 5500691]
Lee M, et al. Effects of hydrogen sulfide-releasing L-DOPA derivatives on glial activation: potential for treating Parkinson’s disease. Biol Chem. 2010 Jun 4;285(23):17318-28. Epub 2010 Apr 5. [PMID: 20368333]
Clark J, et al. Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice. PLoS One. 2010 Aug 23;5(8). pii: e12333.[PMID: 20808797]
Krinsky DL, LaValle JB, Hawkins EB, et al. Natural Therapeutics Pocket Guide. 2nd ed. Hudson (OH): Lexi-Comp; 2003.
Grandjean EM, Berthet P, Ruffmann R, Leuenberger P. Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clinical trials. Clin Ther. 2000 Feb 22(2):209-21. [PMID: 10743980]
Yalçin E, Altin F, Cinhüseyinoglue F, et al. N-acetylcysteine in chronic blepharitis. Cornea. 2002 Mar;21(2):164-8. [PMID: 11862087]
Ottenwalder H, Simon P. Differential effect of N-acetylcysteine on excretion of the metals Hg, Cd, Pb and Au. Arch Toxicol. 1987 Jul;60(5):401-2. [PMID: 3662815]
Keogh JP, Steffen B, Siegers CP. Cytotoxicity of heavy metals in the human small intestinal epithelial cell line I-407: the role of glutathione. J Toxicol Environ Health. 1994 Nov;43(3):351-9. [PMID: 7966443]
Witschi A, et al. The systemic availability of oral glutathione. Eur J Clin Pharmacol. 1992;43:667-9. [PMID: 1362956]
De Rosa SC, et al. N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest 2000 Oct;30(10):841-2. [PMID: 11029607]
Atkuri KR, Mantovani JJ, Herzenberg LA, et al. N-Acetylcysteine—a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007 Aug;7(4):355-9. Review. [PMID: 17602868]
White AC, Thannickal VJ, Fanburg BL. Glutathione deficiency in human disease. J Nutr Biochem. 1994;5:218-26. http://www.sciencedirect.com/ science/article/pii/0955286394900396 Updated January 27, 2003. Accessed February 27, 2012.
Pace GW, Leaf CD. The role of oxidative stress in HIV Disease. Free Rad Biol Med. 1995;19:523-8. [PMID: 7590404]
Favier A, Sappey C, Leclerc P, et al. Antioxidant status and lipid peroxidation in patients infected with HIV. Chem Biol Interact. 1994 Jun;91(2-3):165-80. Review. [PMID: 8194133].
Nakamura H, Masutani H, Yodoi J. Redox imbalance and its control in HIV infection. Antioxid Redox Signal. 2002 Jun;4(3):455-64. [PMID: 12215212]
Roberts RL, Aroda VR, Ank BJ. N-acetylcysteine enhances antibody-dependent cellular toxicity in neutrophils and mononuclear cells from healthy adults and human immunodeficiency virus-infected patients. J Infect Dis. 1995 Dec;172(6):1492-502. [PMID: 7594708]
Hu HL, Forsey RJ, Blades TJ, et al. Antioxidants may contribute in the fight against ageing: an in vitro model. Mech Ageing Dev. 2000 Dec 20;121(1- 3):217-30. [PMID: 11164475] Additional references
Vitamin D3 5000
Tsiaras WG, Weinstock MA. Factors influencing vitamin d status. Acta Derm Venereol. 2011 Mar;91(2):115-24. [PMID: 21384086]
Cannell JJ, Hollis BW. Use of vitamin D in clinical practice. Altern Med Rev. 2008 Mar;13(1):6-20. [PMID: 18377099]
Heany RP. Vitamin D in health and disease. Clin J Am Soc Nephrol. 2008 Sep;3(5):1535-41. [PMID: 18525006]
Dawson-Hughes B, Harris SS, Krall EA, et al. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997;337:670-76. [PMID: 9278463]
Papadimitropoulos E, Wells G, Shea B, et al. Meta-analyses of therapies for postmenopausal osteoporosis. VIII: Meta-analysis of the efficacy of vitamin D treatment in preventing osteoporosis in postmenopausal women. Endocr Rev. 2002;23:560-69. [PMID: 12202471]
Lips P, Bouillon R, van Schoor NM, et al. Reducing fracture risk with calcium and vitamin D. Clin Endocrinol (Oxf). 2010 Sep;73(3):277-85. [PMID: 20796001]
Garland CF, French CB, Baggerly LL, et al. Vitamin d supplement doses and serum 25-hydroxyvitamin d in the range associated with cancer prevention. Anticancer Res. 2011 Feb;31(2):607-11. [PMID: 21378345]
Raman M, Milestone AN, Walters JR, et al. Vitamin D and gastrointestinal diseases: inflammatory bowel disease and colorectal cancer. Therap Adv Gastroenterol. 2011 Jan;4(1):49-62. [PMID: 21317994]
Humble MB. Vitamin D, light and mental health. J Photochem Photobiol B. 2010 Nov;101(2):142-49. [PMID: 18445674]
Grant WB, Soles CM. Epidemiologic evidence supporting the role of maternal vitamin D deficiency as a risk factor for the development of infantile autism. Dermatoendocrinol. 2009 Jul;1(4):223-28. [PMID: 20592795]
Currenti SA. Understanding and determining the etiology of autism. Cell Mol Neurobiol. 2010 Mar;30(2):161-71. [PMID: 19774457]
Naito M, Miyaki K, Naito T, et al. Association between vitamin D receptor gene haplotypes and chronic periodontitis among Japanese men. Int J Med Sci. 2007 Aug;4(4):216-22. [PMID: 17848979]
McGrath JJ, Burne TH, Féron F, et al. Developmental vitamin D deficiency and risk of schizophrenia: a 10-year update. Schizophr Bull. 2010 Nov;36(6):1073- 78. [PMID: 20833696]
Gandini S, Boniol M, Haukka J, et al. Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma. Int J Cancer. 2011 Mar;128(6):1414-24. doi: 10.1002/ ijc.25439. [PMID: 20473927]
Yin L, Grandi N, Raum E, et al. Meta-analysis: circulating vitamin D and ovarian cancer risk. Gynecol Oncol. 2011 Feb 14. [Epub ahead of print] [PMID: 21324518]
Grant WB, Goldstein M, Mascitelli L. Ample evidence exists from human studies that vitamin D reduces the risk of selected bacterial and viral infections. Exp Biol Med (Maywood). 2010 Dec;235(12):1395-96; discussion 1397. [PMID: 21171208]
Beard JA, Bearden A, Striker R. Vitamin D and the anti-viral state. J Clin Virol. 2011 Mar;50(3):194-200. [PMID: 21242105]
Hertting O, Holm Å, Lüthje P, et al. Vitamin D induction of the human antimicrobial peptide cathelicidin in the urinary bladder. PLoS One. 2010 Dec;5(12):e15580. [PMID: 21179490]
Grant WB, Boucher BJ. Requirements for vitamin D across the life span. Biol Res Nurs. 2011 Jan 17. [Epub ahead of print] [PMID: 21242196]
Heaney RP, Recker RR, Grote J, et al. Vitamin d3 is more potent than vitamin d2 in humans. J Clin Endocrinol Metab. 2011 Mar;96(3):E447-52. [PMID: 21177785]
MCHC plus Mag
Pines A, Raafat H, Lynn AH, et al. Clinical trial of microcrystalline hydroxyapatite compound (‘MCHC plus Mag’) in the prevention of osteoporosis due tocorticosteroid therapy. Curr Med Res Opin. 1984;8(10):734-42. [PMID: 6373153]
Stellon A, Davies A, Webb A, et al. Microcrystalline hydroxyapatite compound in prevention of bone loss in corticosteroid-treated patients with chronic active hepatitis. Postgrad Med J. 1985 Sep;61(719):791-6. [PMID: 2997764]
Buclin T, Jacquet AF, Burckhardt P. Intestinal absorption of calcium gluconate and oseine-mineral complex: an evaluation by conventional analyses [in French]. Schweiz Med Wochenschr. 1986 Dec 13;116(50):1780-3. [PMID: 3026039]
Epstein O, Kato Y, Dick R, et al. Vitamin D, hydroxyapatite, and calcium gluconate in treatment of cortical bone thinning in postmenopausal women with primary biliary cirrhosis. Am J Clin Nutr. 1982 Sep;36(3):426-30. [PMID: 6287835]
Stepan JJ, Mohan S, Jennings JC, et al. Quantitation of growth factors in ossein-mineral-compound. Life Sci. 1991;49(13):PL79-84. [PMID: 1653384]
Annefeld M, Caviezel R, Schacht E, et al. The influence of ossein-hydroxyapatite compound (‘MCHC plus Mag’) on the healing of a bone defect. Curr Med Res Opin. 1986;10(4):241-50. [PMID: 3022988]
Fernández-Pareja A, Hernández-Blanco E, Pérez-Maceda JM, et al. Prevention of osteoporosis: four-year follow-up of a cohort of postmenopausal women treated with an ossein-hydroxyapatite compound. Clin Drug Investig. 2007;27(4):227- 32. [PMID: 17358094]
Rüegsegger P, Keller A, Dambacher MA. Comparison of the treatment effects of ossein-hydroxyapatite compound and calcium carbonate in osteoporotic females. Osteoporos Int. 1995 Jan;5(1):30-4. [PMID: 7703621]
Khadzhiev A, Rachev E, Katsarova M, et al. The results of a clinical trial of the preparation MCHC plus Mag [in Bulgarian]. Akush Ginekol (Sofiia). 1990;29(4):85-7. [PMID: 2176437]
Castelo-Branco C, Martínez de Osaba MJ, Pons F, et al. Ossein-hydroxyapatite compounds for preventing postmenopausal bone loss. Coadjuvant use with hormone replacement therapy. J Reprod Med. 1999 Mar;44(3):241-6. [PMID: 10202741]
Castelo-Branco C, Pons F, Vicente JJ, et al. Preventing postmenopausal bone loss with ossein-hydroxyapatite compounds. Results of a two-year, prospective trial. J Reprod Med. 1999 Jul;44(7):601-5. [PMID: 10442322]
Bovine Spongiform Encephalopathy Status of Members. OIE-World Organization for Animal Health Web site. http://www.oie.int/animal-health-in-the-world/ official-disease-status/bse/list-of-bse-risk-status/. Accessed May 9, 2014.
Malic acid can be the right ligand for certain applications. Albion® Research Notes. April 2003;12(2). http://www.albionhumannutrition.com/research-notes/ download?start=40. Accessed May 9, 2014.
Parsons WB Jr, Achor RW, Berge KG,et al. Changes in concentration of blood lipids following prolonged administration of large doses of nicotinic acid to persons with hypercholesterolemia: preliminary observations. Mayo Clin Proc. 1956 Jun 27;31(13):377-90. [PMID: 13336128]
Kannel WB. Recent findings from the Framingham study—I. Med Times. 1978 Apr;106(4):23-27. [PMID: 642745]
Hulley SB. The US National Cholesterol Education Program. Adult treatment guidelines. Drugs. 1988;36 Suppl 3:100-04. [PMID: 3254822]
Morgan JM, Carey CM, Lincoff A, et al. The effects of niacin on lipoprotein subclass distribution. Prev Cardiol. 2004 Fall;7(4):182-7; quiz 188. [PMID: 8424822]
Holland RE, Rahman K, Morris AI, et al. Effect of niacin on biliary lipid output in the rat. Biochem Pharmacol. 1993 Jan 7;45(1):43-49. [PMID: 8424822]
Niacin. http://www.naturalstandard.com/naturalstandard/monographs/ monoframeset.asp?monograph=/monographs/herbs supplements/aux2-niacin. asp&patientVersion=/monographs/herbs supplements/patient-niacin. Accessed August 19, 2010.
Taylor AJ, Sullenberger LE, Lee HJ, et al. Biology for the investigation of the treatment effects of reducing cholesterol (ARBITER) 2: a double-blind, placebo controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins. Circulation. 2004 Dec 7;110(23):3512-17. [PMID: 15537681]
Villines TC, Stanek EJ, Devine PJ, et al. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration. J Am Coll Cardiol. 2010 Jun 15;55(24):2721-67. [PMID: 20399059]
Michos ED, Sibley CT, Baer JT, et al. Niacin and statin combination therapy for atherosclerosis regression and prevention of cardiovascular disease events: reconciling the AIM-HIGH (Atherothrombosis intervention in metabolic syndrome with low hdl/high triglycerides: Impact on global health outcomes) trial with previous surrogate endpoint trials. J Am Coll Cardiol. 2012 Apr 4. [Epub ahead of print] [PMID: 22520249]
Keenan JM, Fontaine PL, Wenz JB, et al. Niacin revisited. A randomized, controlled trial of wax-matrix sustained-release niacin in hypercholesterolemia. Arch Intern Med. 1991 Jul;151(7):1424-32. [PMID: 2064495]
Aronov DM, Keenan JM, Akhmedzhanov NM, et al. Clinical trial of wax-matrix sustained-release niacin in a Russian population with hypercholesterolemia. Arch Fam Med. 1996 Nov-Dec;5(10):567-75. [PMID: 8930228]
Backes JM, Padley RJ, Moriarty PM. Important considerations for treatment with dietary supplement versus prescription niacin products. Postgrad Med. 2011 Mar;123(2):70-83. Review. [PMID: 21474895] Norris RB. “Flush-free niacin”: dietary supplement may be “benefit-free”. Prev Cardiol. 2006 Winter;9(1):64-65. [PMID: 16407706]
McKenney JM. A comparison of the efficacy and toxic effects of sustained- vs immediate-release niacin in hypercholesterolemic patients. JAMA. 1994 Mar 2;271(9):672-77. [PMID: 8309029]
McKenney JM. Pharmacologic options for aggressive low-density lipoprotein cholesterol lowering: benefits versus risks. Am J Cardiol. 2005 Aug 22;96(4A):60E-66E. Review. [PMID: 16098846]